منابع مشابه
Kidney Diseases Caused by Complement Dysregulation: Acquired, Inherited, and Still More to Come
Inherited and acquired dysregulation of the complement alternative pathway plays an important role in multiple renal diseases. In recent years, the identification of disease-causing mutations and genetic variants in complement regulatory proteins has contributed significantly to our knowledge of the pathogenesis of complement associated glomerulopathies. In these diseases defective complement c...
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Inherited kidney diseases have been recognized in several breeds or kindreds of dogs and cats, and more examples of such conditions are likely to be identified as renal diseases that occur in a familial pattern are investigated thoroughly. In affected breeds/kindreds, accurate diagnosis of familial nephropathies is especially important because of the potential health and selective breeding impl...
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The recurrence of renal disease after renal transplantation is becoming one of the main causes of graft loss after kidney transplantation. This principally concerns some of the original diseases as the atypical hemolytic uremic syndrome (HUS), the membranoproliferative glomerulonephritis (MPGN), in particular the MPGN now called C3 glomerulopathy. Both this groups of renal diseases are characte...
متن کاملComplement in Non-Antibody-Mediated Kidney Diseases
The complement system is part of the innate immune response that plays important roles in protecting the host from foreign pathogens. The complement components and relative fragment deposition have long been recognized to be strongly involved also in the pathogenesis of autoantibody-related kidney glomerulopathies, leading to direct glomerular injury and recruitment of infiltrating inflammation...
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At least 10% of adults and nearly all children who receive renal-replacement therapy have an inherited kidney disease. These patients rarely die when their disease progresses and can remain alive for many years because of advances in organ-replacement therapy. However, these disorders substantially decrease their quality of life and have a large effect on health-care systems. Since the kidneys ...
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ژورنال
عنوان ژورنال: Clinical Journal of the American Society of Nephrology
سال: 2021
ISSN: 1555-9041,1555-905X
DOI: 10.2215/cjn.11830720